| Agent / Marker | Use | Laboratory |
|---|---|---|
| A20/TNFAIP3 | ubiquitin-editing enzyme (breast cancer) | UGA |
| ACTH | Adrenocorticotrophic hormone | Cornell, Michigan, TAMU, UCDavis |
| Actin | CSU, Nebraska | |
| AgNOR | index for assessment of proliferating cells | Michigan |
| alpha-antitrypsin | Cornell | |
| alpha-fetoprotein | embryonal stem cells | Cornell, TAMU |
| alpha-inhibin | GCT, ovarian tumors | Cornell, Michigan, Purdue, TAMU, UCDavis |
| Anti-Müllerian Hormone | gonadal tumors | Cornell |
| Anti-Myelin Protein Zero | Cornell | |
| Apotag kit (rabbit) | Apoptosis | CPath-UGA |
| Aquaporin-2 | water channel protein | Michigan |
| BCL-2 | B cells | Michigan |
| BCL-6 | B cells | Michigan |
| Beta-Amyloid Precursor Protein | Alzheimers disease | Cornell |
| Beta-catenin | tumor marker | Cornell |
| Beta-III-tubulin | melanoma | Cornell |
| BLA36 | B lymphocyte antigen | CPath-UGA, Cornell, Purdue |
| Calbindin | neurons | Michigan |
| Calcitonin | C-cell tumors | CPath-UGA, Cornell, CSU, KSU, LADDL, Michigan, Purdue, TAMU, UCDavis, UGA |
| Calponin | myoepithelial cells | Cornell, Michigan, Purdue, TAMU |
| Calretinin | Mesothelioma | Cornell, Michigan, Purdue, TAMU, UCDavis, UGA |
| Caspase (general) | TAMU | |
| Caspase 3, cleaved | Apoptosis | UGA |
| CD117 (c-kit) | C-kit- Mast cell tumors, GIST | CPath-UGA, Cornell, CSU, KSU, LADDL, Michigan, NC, ND, Nebraska, Purdue, TAMU, UCDavis, UGA, UF |
| CD11b | CD8+ cytotoxic T cell | TAMU |
| CD11d | Hemophagocytic histiocytic sarcoma subtype | LADDL, Michigan, Purdue, TAMU, UGA |
| CD14 | monocyte/macrophage cell lineage | UGA |
| CD163 | monocyte/macrophage specific marker | LADDL, Michigan, Purdue, UCDavis |
| CD163 (equine) | LADDL | |
| CD172a (equine)- frozen only | LADDL | |
| CD18 | species unspecified | CSU, KSU, TAMU, WSU |
| CD18 (canine) | CLAD, leukocyte adhesion integrin | Cornell, LADDL, Michigan, Nebraska, Purdue, UGA |
| CD18 (equine) | LADDL | |
| CD18 (feline) | Macrophages | LADDL, Michigan, Purdue |
| CD18 (mouse) | Macrophages | CPath-UGA |
| CD2 (equine)- frozen only | LADDL | |
| CD20 | B-lymphocytes | Cornell, CSU, Iowa, KSU, LADDL, Michigan, NC, ND, Purdue, TAMU, TVMDL, UGA, UF, WSU |
| CD20 (equine) | LADDL | |
| CD204 | Canine histiocytic sarcoma | Cornell, CSU, LADDL, Michigan, Purdue, UGA |
| CD204 (equine) | LADDL | |
| CD21 | Dendritic cell marker | UGA |
| CD21 (equine)- frozen only | LADDL | |
| CD21 (mouse) | Dendritic cell marker | CPath-UGA |
| CD25 | Alpha subunit of interleukin-2 receptor | UGA |
| CD25 (equine) | LADDL | |
| CD3 | T-lymphocytes | Cornell, CSU, Iowa, KSU, LADDL, Michigan, NC, ND, Nebraska, Purdue, TAMU, TVMDL, UF, WSU |
| CD3 (equine) | LADDL | |
| CD3 (equine)- UC F6G-3; frozen only | LADDL | |
| CD3 (mouse primary ab) | T-lymphocytes (use in rabbits) | UGA |
| CD3 (rabbit primary ab) | T-lymphocytes (not for rabbits) | CPath-UGA, UGA |
| CD31 | PECAM-1, platelet endothelial cell adhesion molecule 1, blood vessels | Cornell, CSU, LADDL, Michigan, Purdue, TAMU, UCDavis, UGA |
| CD31 (equine)- PECAM-1 | LADDL | |
| CD34 | mature mast cells | Michigan, TAMU |
| CD4 (equine)- frozen only | LADDL | |
| CD45 | TCR signaling | Purdue, TAMU, UGA |
| CD45 (canine) | TCR signaling | Michigan |
| CD45-B220 | Cornell | |
| CD45-RA | leukocyte common antigen | Cornell, UGA |
| CD5 (equine)- frozen only | B lymphocytes | LADDL |
| CD61 (feline) | normal and abnormal megakaryocytes and occasional endothelial cells | LADDL |
| CD68 (ruminant) | monocytic phagocytes, osteoclasts | Purdue |
| CD79 (mouse) | B-lymphocytes (CD20 is better) | CPath-UGA |
| CD79a | B-lymphocytes (CD20 is better) | CSU, KSU, LADDL, ND, Purdue, TAMU, UGA, UF |
| CD8 (equine)- frozen only | T-cells | LADDL |
| CD83 (equine)- frozen only | Antigen Presenting Cells | LADDL |
| CD86 (equine)- frozen only | T cell activation | LADDL |
| CDX-2 | colorectal origin of metastatic carcinoma | Purdue |
| Chromogranin A | Neuroendocrine tissues | CPath-UGA, Cornell, CSU, LADDL, Michigan, Purdue, TAMU, UCDavis, UGA, UF |
| Chromogranin A (SP‐1 porcine) | Neuroendocrine tissues | KSU |
| Claudin 1 | cancer prognosis marker | Michigan |
| Claudin 5 | endothelial cells | KSU |
| CNPase | Cornell, CSU, Purdue | |
| Collagen IV | Purdue, UConn | |
| Complement 3 (C3) | UCDavis | |
| COX-1 | Purdue | |
| COX-2 | Cyclooxygenase 2 | CPath-UGA, Michigan, UGA |
| Cyclin D1 | cancer prognosis marker | Michigan |
| Cyclin D3 | cancer prognosis marker | Michigan |
| Cytokeratin 14 | basal cells of stratified epithelium | UCDavis |
| Cytokeratin 19 | thyroid tumors | Cornell, Michigan |
| Cytokeratin 20 | tumors of the GI epithelium, urothelium, and Merkel cell | Cornell, Michigan, TAMU, UCDavis |
| Cytokeratin 5 | mesothelioma | Purdue |
| Cytokeratin 5/6 | basal cells or myoepithelial cells | Michigan, UCDavis, UGA |
| Cytokeratin 7 | CK7; + mammary gland carcinomas and canine cholangiocarcinomas | Cornell, CSU, LADDL, Michigan, Purdue, TAMU, UCDavis |
| Cytokeratin 8 (CAM 5.2) | carcinoma | UCDavis |
| Cytokeratin HMW | Cytokeratins 1, 5, 10 and 14 (carcinomas) | Michigan, Purdue, UCDavis, UGA |
| Cytokeratin LMW | UCDavis | |
| Cytokeratin LMW 8/18 | Apocrine sweat glands (double 8/18), single CK8-expression (hair follicle tumors) | Purdue, UCDavis, UGA |
| Cytokeratin Plus, Pan AE1/AE3 + 8/18 | UGA | |
| Cytokeratin, Pan (MNF116) | LADDL, Michigan | |
| Cytokeratin, Pan AE1/AE3 | CPath-UGA, Cornell, CSU, KSU, LADDL, Michigan, NC, ND, Nebraska, Purdue, TAMU, UCDavis, UGA, UF, WSU | |
| Cytokeratin, Pan Lu-5 | Multiple cytokeratins (clone Lu5) | UCDavis, UGA |
| D2-40 | podoplanin; germ cells and lymphatic endothelium | UConn |
| Desmin | Filament of skeletal and cardiac muscle | CPath-UGA, Cornell, CSU, KSU, LADDL, Michigan, Nebraska, ND, Purdue, TAMU, UCDavis, UGA, UF, WSU |
| Desmoglein 1 and 2 | skin junctions | Michigan |
| Desmoplakin 1 and 2 | skin junctions | Michigan |
| DOG-1 | canine GIST | CSU |
| Doublecortin (DCX) | Marker for neurogenesis | UGA |
| E-Cadherin | Cadherin, cell adhesion molecule (breast cancer) | CPath-UGA, Cornell, CSU, Michigan, Purdue, TAMU, UCDavis, UGA |
| EGFR | Epidermal Growth Factor Receptor; cancer marker | UGA |
| Endorphin | Neural tissue | Michigan |
| Epithelial Membrane Antigen | epithelial cells of all types, mesothelial cells, perineural cells, and a subset of plasma cells | UConn |
| ER | Estrogen | Michigan |
| ETV1 (RNAscope) | canine GIST oncogene | Cornell |
| Factor VIII related antigen | Blood vessels | CPath-UGA, CSU, KSU, LADDL, Michigan, Nebraska, ND, Purdue, TAMU, UCDavis, UGA, UF, WSU |
| Factor XIII-A | skin | UGA |
| Factor XIII-B | skin | UGA |
| FoxP3 | Treg cells | Cornell, UGA |
| FSH | Follicle stimulating hormone | Michigan |
| Gastrin | G cells of stomach/ islets | Cornell, Michigan, Purdue, TAMU |
| GATA-3 | breast cancer prognostic | Purdue |
| GFAP (Glial Fibrillary Acidic Protein) | Neural tissue | CPath-UGA, Cornell, CSU, KSU, LADDL, Michigan, Nebraska, ND, Purdue, TAMU, UCDavis, UGA, UF, WSU |
| GH | Growth hormone | Michigan, UCDavis |
| Glucagon | alpha cells of islets | CPath-UGA, Cornell, Michigan, TAMU, UCDavis, UGA |
| Glut1 | Glucose receptor | Purdue |
| Granzyme B | apoptosis, tissue rejection | UCDavis, UGA |
| HBME-1 | thyroid tumors | Purdue |
| Hepatocyte Specific Antigen (HSA) | Hepatocellular Carcinomas | Purdue, TAMU, UGA |
| HepPar-1 | hepatocellular carcinoma | Cornell, CSU, Michigan, TAMU |
| Her2 | Mammary carcinoma | Michigan, UGA |
| Histamine | Mast cells | UGA |
| HMB45 | melanoma | Michigan |
| IBA-1 | Histiocytes/ microglia/ macrophages | Cornell, CSU, Iowa, LADDL, Nebraska, NC, ND, TAMU, UCDavis, UGA, UF |
| IgA (bovine) | UGA | |
| IgA (canine) | Michigan, UCDavis | |
| IGF2 (Insulin-like Growth Factor) | proliferation and apoptosis | UGA |
| IgG (canine) | KSU, Michigan, UCDavis, UGA | |
| IgG (equine) | UGA | |
| IgG (no species given) | Nebraska | |
| IgM (canine) | KSU, Michigan, UCDavis | |
| INSM1 | insulinoma-associated protein 1- neuroendocrine tumors | UGA |
| Insulin | islet beta cells | CPath-UGA, Cornell, CSU, KSU, LADDL, Michigan, Purdue, TAMU, UCDavis, UGA, UF |
| Kappa light chains | Michigan, LADDL | |
| Ki67 | proliferation marker | CPath-UGA, Cornell, CSU, KSU, LADDL, Michigan, Nebraska, Purdue, TAMU, UCDavis, UGA |
| Ki67 (red) | Michigan | |
| Lambda light chain antibodies | Michigan, TAMU, LADDL | |
| Laminin | Carcinoma, PNST | Michigan, UCDavis |
| LH | Luteinizing hormone | Michigan |
| Lipoteichoic acid | Cornell | |
| Luna's method (Histochemical) | eosinophils | UF |
| Lysozyme | CPath-UGA, CSU, KSU, LADDL, Purdue, TAMU, UCDavis, UGA | |
| MAC387 | macrophages | CPath-UGA, Cornell, TAMU, UGA |
| Macrophage/microglia marker | Purdue | |
| MAP2 | Cornell | |
| Melan A | melanoma | CPath-UGA, Cornell, CSU, KSU, LADDL, Michigan, NC, ND, Nebraska, Purdue, TAMU, UCDavis, UGA, WSU |
| Met-enkephalin | GI-neuroendocrine | Michigan |
| MHC II (HLA-DR) | CSU, LADDL, Purdue, UGA | |
| Microglia | TAMU | |
| MITF | Microphthalmia Transcription Factor- melanoma | Michigan |
| MUM1 | Plasma cells | Cornell, CSU, KSU, LADDL, Michigan, NC, ND, Purdue, TAMU, UCDavis, UGA, UF, WSU |
| Muscle specific actin | Cornell, Michigan, Purdue, TAMU, UF, WSU | |
| Myelin Basic Protein (MBP) | SMI94; myelin | CPath-UGA, LADDL, UCDavis, UGA |
| Myeloid/histiocytic antigen | calprotectin | Purdue, LADDL |
| Myeloperoxidase | Cornell, TAMU, UCDavis | |
| Myogenin (Mygo) | UCDavis | |
| Myoglobin | skeletal muscle | Cornell, LADDL, Michigan, TAMU, UCDavis, UGA |
| Myoglobin D1 | skeletal muscle | Nebraska, TAMU |
| Myosin smooth muscle | Purdue | |
| Napsin A | lung adenocarcinoma | Purdue |
| Natural Killer | Call- have not had in past | Purdue |
| Nerve growth factor receptor | NGFR | Purdue |
| NeuN (Neuronal Nuclear Antigen & Neuron) | neuronal differentiation | Cornell, UCDavis, UGA |
| Neurofilament | CPath-UGA, Cornell, CSU, LADDL, Michigan, Purdue, TAMU, UCDavis, UGA | |
| Neuron Specific Enolase (NSE) | Non-specific stain | CPath-UGA, Cornell, KSU, LADDL, Michigan, Purdue, TAMU, UCDavis, UGA, UF |
| NOS2 | Nitric oxide synthase 2- oral SCC | UGA |
| OLIG2 | oligodendroglioma | Cornell, CSU, Purdue, TAMU, UCDavis, UGA |
| Osteocalcin | CSU | |
| Osteonectin (hSPARC) | Michigan, UCDavis, UGA | |
| p16 | papilloma virus related cancer | Michigan |
| p53 | cancer | CPath-UGA, Michigan |
| p63 | SCC-cancer prognosis marker | Michigan, Purdue |
| Pan Muscle Actin | UCDavis | |
| Pancreatic polypeptide (IAPP) | amylin; islet amyloid | Michigan, Purdue |
| Pancreatic trypsin | CSU | |
| Panel- CD3 and CD20 | Lymphoma panel | TAMU |
| Panel- CD3, CD79 or CD20 | Lymphoma Panel | UGA |
| Panel- CD3, CD79 or CD20, CD18, MHCII, Mac387, IBA1 | Histiocytic Sarcoma Panel | UGA |
| Panel- CD3, CD79, CD20 and CD21 | Lymphoma Panel | UGA |
| Panel- CD3, PAX5, CD20, BA-1 | Leukocyte panel | Cornell |
| Panel- CD3, PAX5, CK19, LTA, TLR-4 | CCHS (histocytic sarcoma) panel | Cornell |
| Panel- Chromogranin A, Synaptophysin, NSE | Neuroendocrine Panel | UGA |
| Panel- Cytokeratin: AE1/AE3, Lu-5, Vimentin, S100 | Undifferentiated Tumor Panel | UGA |
| Panel- cytokeratins AE1/AE3, Lu-5, 5&6, LMW and HMW | Carcinoma Panel | UGA |
| Panel- EGFR, Her-2, PDGF, PDGF-r, VEGF, VEGF-r, SCF and KIT | Tyrosine kinase/recepto panel (cancer) | Michigan |
| Panel- GFAP, S100, Neurofilament, OLIG2 | Neural Panel | UGA |
| Panel- Her-2, ER, PR, CK5/6, EGFR, ki67, p63, E-cad and P-cad | Mammary tumor prognosis | Michigan |
| Panel- Insulin, Glucagon, Somatostatin | Pancreatic Islet Panel | UGA |
| Panel- Ki67, c-KIT, AgNOR | Mast Cell Tumor Prognostic Panel | UGA |
| Panel- Lysozyme, E-Cad, CD11d, CD45, CD45RA | Secondary Histiocytic Sarcoma Panel | UGA |
| Panel- Melan A and PNL-2 | Melanoma panel | TAMU |
| Panel- Melan A, PNL2, S100 | Melanoma Panel | UGA |
| Panel- Pan cytokeratin and vWF | Epithelioid Hemangiosarcoma Panel | TAMU |
| Panel- s Melan A, PNL-2, TRP-1, TRP-2 | Melanoma cocktail | Michigan |
| Panel- SMA and c-kit | GIST panel | TAMU |
| Panel- vimentin, desmin, myoglobin, SMA (smooth muscle actin), S100, Factor VIIIra and CD31 | Undifferentiated Sarcoma | UGA |
| Panel-Alkaline phosphatase and RUNX2 | Osteosarcoma panel | TAMU |
| PARR testing (FFPE block) | hematologic cancers | Michigan |
| PAX-5 (Avian) | B-lymphocytes | Cornell |
| PAX-5 (Mammalian) | B-lymphocytes | Cornell, CSU, LADDL, Michigan, NC, ND, Nebraska, Purdue, UCDavis, UGA |
| PAX-8 | marker for thyroid, renal, Müllerian, and thymic tumors | Purdue |
| PCNA | Proliferating Cell Nuclear Antigen- cancer marker | CPath-UGA, Cornell, Michigan, Purdue, TAMU, UGA |
| PDL-1 | cancer prognostic | UGA |
| Periaxin | Devil facial tumors, schwannomas | Cornell, Purdue, UCDavis |
| PGP 9.5 | neural and neuroendocrine tissues | Cornell, Michigan, Purdue, UGA |
| Pinkerton (histochemical) | inclusion bodies -rickettsia | UF |
| PNL2 | Melanoma | Cornell, CSU, KSU, LADDL, Michigan, NC, Purdue, TAMU, UCDavis, UGA, UF, WSU |
| PR | Progesterone | Michigan |
| Prostate specific antigen | Purdue | |
| Prostatic acid phosphatase | prostatic epithelial cells | Michigan, UCDavis |
| PROX-1 | Lymphatic vessels | Cornell, UGA |
| PTH | Parathyroid Hormone | Cornell, LADDL, TAMU, UCDavis, UGA |
| PTH (canine) | Parathyroid hormone (does not work in cats) | Michigan |
| PTH-rp | Parathyroid Hormone-Related Peptide- tumors | UGA |
| Rack-1 | IGF-1R and integrin signaling | Purdue |
| RUNX2 | Osteoblast differentiation | UGA, TAMU |
| S-100 | neural tissues | CPath-UGA, Cornell, CSU, KSU, LADDL, Michigan, Nebraska, Purdue, TAMU, UCDavis, UGA |
| S100 P | Purdue | |
| Sarcomeric actin | Cornell, LADDL, Purdue, TAMU | |
| Skeletal myosin | UCDavis | |
| SMI 31 | Phosphorylated NF H & M | UCDavis |
| SMI 312 | General pan axonal marker | UCDavis |
| SMI 33 | Nonphosphorylated NF H & M | UCDavis |
| SMI 36 | Phosphorylated NF H | UCDavis |
| SMI 91 | Myelin CNPase | UCDavis |
| Smooth Muscle Actin (SMA) | smooth muscle | CPath-UGA, Cornell, KSU, LADDL, Michigan, ND, Purdue, TAMU, UCDavis, UGA, UF |
| Somatostatin | neuroendocrine (hypothalamus, islets, gastric) | Cornell, KSU, LADDL, Michigan, Purdue, UCDavis, UGA |
| SOX10 | melanocytic and schwannian tumors, PNST | LADDL, Michigan, TAMU, UGA |
| SOX2 | multipotential neural stem cells | Cornell |
| SSTR2 | somatostatinoma | Cornell |
| Surfactant | Michigan, UCDavis | |
| Synaptophysin | Neuroendocrine cells | CPath-UGA, Cornell, CSU, KSU, LADDL, Michigan, Nebraska, Purdue, TAMU, UCDavis, UGA, UF, WSU |
| Tamm-Horsfall Protein | urinary protein | Michigan |
| Thy-1 (CD90) | CD90- lymphocytes | Michigan, Purdue |
| Thyroglobulin | Thyroid follicular cells | CPath-UGA, Cornell, CSU, KSU, LADDL, Michigan, Purdue, TAMU, UCDavis, UGA |
| TLR-4 | Toll like receptor (LPS) | Cornell |
| Triple Neurofilament Protein (TNP) | UCDavis | |
| TRP-1 | Melanoma | TAMU, LADDL |
| TRP-2 | Melanoma | TAMU, LADDL |
| Tryosine hydroxylase | Pheochromocytoma | Purdue, TAMU |
| Tryptase | mast cells | CSU, KSU, Michigan, Nebraska, Purdue, UCDavis |
| TTF-1 | Thyroid Transcription Factor (thyroid and lung- nuclear stain) | Cornell, CSU, KSU, Purdue, TAMU, UCDavis, UGA, UF |
| TTF-1 (canine) | dog only | Michigan |
| Uroplakin II | Bladder tumors | Purdue |
| Uroplakin III | Bladder tumors | Cornell, CSU, Michigan, Purdue, TAMU, UCDavis |
| Vasoactive intestinal protein | GI inflammation | Michigan |
| VEGF | blood vessels | CSU |
| Villin | colorectal and gastrointestinal cancer | Michigan |
| Vimentin | Mesenchymal | CPath-UGA, Cornell, CSU, KSU, LADDL, Michigan, ND, Nebraska, NC, Purdue, TAMU, UCDavis, UF, WSU |
| Vimentin SP20 | Mesenchymal | UGA |
| Vimentin V9 | Mesenchymal | UGA |
| von Willebrand factor (vWF) | Cornell, NC, TAMU | |
| Wilms Tumor 1 (WT1) | Nephroblastoma | CPath-UGA, Cornell, Michigan, UGA |
| YFP | Yellow Fluorescent Protein- recombinant marker | UGA |