Veterinary Immunohistochemistry (IHC) Database

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Cellular Markers (IHC)

Agent / Marker Use Laboratory
A20/TNFAIP3 ubiquitin-editing enzyme (breast cancer) UGA
ACTH Adrenocorticotrophic hormone Cornell, Michigan, TAMU, UCDavis
Actin CSU, Nebraska
AgNOR index for assessment of proliferating cells Michigan
alpha-antitrypsin Cornell
alpha-fetoprotein embryonal stem cells Cornell, TAMU
alpha-inhibin GCT, ovarian tumors Cornell, Michigan, Purdue, TAMU, UCDavis
Anti-Müllerian Hormone gonadal tumors Cornell
Anti-Myelin Protein Zero Cornell
Apotag kit (rabbit) Apoptosis CPath-UGA
Aquaporin-2 water channel protein Michigan
BCL-2 B cells Michigan
BCL-6 B cells Michigan
Beta-Amyloid Precursor Protein Alzheimers disease Cornell
Beta-catenin tumor marker Cornell
Beta-III-tubulin melanoma Cornell
BLA36 B lymphocyte antigen CPath-UGA, Cornell, Purdue
Calbindin neurons Michigan
Calcitonin C-cell tumors CPath-UGA, Cornell, CSU, KSU, LADDL, Michigan, Purdue, TAMU, UCDavis, UGA
Calponin myoepithelial cells Cornell, Michigan, Purdue, TAMU
Calretinin Mesothelioma Cornell, Michigan, Purdue, TAMU, UCDavis, UGA
Caspase (general) TAMU
Caspase 3, cleaved Apoptosis UGA
CD117 (c-kit) C-kit- Mast cell tumors, GIST CPath-UGA, Cornell, CSU, KSU, LADDL, Michigan, NC, ND, Nebraska, Purdue, TAMU, UCDavis, UGA, UF
CD11b CD8+ cytotoxic T cell TAMU
CD11d Hemophagocytic histiocytic sarcoma subtype LADDL, Michigan, Purdue, TAMU, UGA
CD14 monocyte/macrophage cell lineage UGA
CD163 monocyte/macrophage specific marker LADDL, Michigan, Purdue, UCDavis
CD163 (equine) LADDL
CD172a (equine)- frozen only LADDL
CD18 species unspecified CSU, KSU, TAMU, WSU
CD18 (canine) CLAD, leukocyte adhesion integrin Cornell, LADDL, Michigan, Nebraska, Purdue, UGA
CD18 (equine) LADDL
CD18 (feline) Macrophages LADDL, Michigan, Purdue
CD18 (mouse) Macrophages CPath-UGA
CD2 (equine)- frozen only LADDL
CD20 B-lymphocytes Cornell, CSU, Iowa, KSU, LADDL, Michigan, NC, ND, Purdue, TAMU, TVMDL, UGA, UF, WSU
CD20 (equine) LADDL
CD204 Canine histiocytic sarcoma Cornell, CSU, LADDL, Michigan, Purdue, UGA
CD204 (equine) LADDL
CD21 Dendritic cell marker UGA
CD21 (equine)- frozen only LADDL
CD21 (mouse) Dendritic cell marker CPath-UGA
CD25 Alpha subunit of interleukin-2 receptor UGA
CD25 (equine) LADDL
CD3 T-lymphocytes Cornell, CSU, Iowa, KSU, LADDL, Michigan, NC, ND, Nebraska, Purdue, TAMU, TVMDL, UF, WSU
CD3 (equine) LADDL
CD3 (equine)- UC F6G-3; frozen only LADDL
CD3 (mouse primary ab) T-lymphocytes (use in rabbits) UGA
CD3 (rabbit primary ab) T-lymphocytes (not for rabbits) CPath-UGA, UGA
CD31 PECAM-1, platelet endothelial cell adhesion molecule 1, blood vessels Cornell, CSU, LADDL, Michigan, Purdue, TAMU, UCDavis, UGA
CD31 (equine)- PECAM-1 LADDL
CD34 mature mast cells Michigan, TAMU
CD4 (equine)- frozen only LADDL
CD45 TCR signaling Purdue, TAMU, UGA
CD45 (canine) TCR signaling Michigan
CD45-B220 Cornell
CD45-RA leukocyte common antigen Cornell, UGA
CD5 (equine)- frozen only B lymphocytes LADDL
CD61 (feline) normal and abnormal megakaryocytes and occasional endothelial cells LADDL
CD68 (ruminant) monocytic phagocytes, osteoclasts Purdue
CD79 (mouse) B-lymphocytes (CD20 is better) CPath-UGA
CD79a B-lymphocytes (CD20 is better) CSU, KSU, LADDL, ND, Purdue, TAMU, UGA, UF
CD8 (equine)- frozen only T-cells LADDL
CD83 (equine)- frozen only Antigen Presenting Cells LADDL
CD86 (equine)- frozen only T cell activation LADDL
CDX-2 colorectal origin of metastatic carcinoma Purdue
Chromogranin A Neuroendocrine tissues CPath-UGA, Cornell, CSU, LADDL, Michigan, Purdue, TAMU, UCDavis, UGA, UF
Chromogranin A (SP‐1 porcine) Neuroendocrine tissues KSU
Claudin 1 cancer prognosis marker Michigan
Claudin 5 endothelial cells KSU
CNPase Cornell, CSU, Purdue
Collagen IV Purdue, UConn
Complement 3 (C3) UCDavis
COX-1 Purdue
COX-2 Cyclooxygenase 2 CPath-UGA, Michigan, UGA
Cyclin D1 cancer prognosis marker Michigan
Cyclin D3 cancer prognosis marker Michigan
Cytokeratin 14 basal cells of stratified epithelium UCDavis
Cytokeratin 19 thyroid tumors Cornell, Michigan
Cytokeratin 20 tumors of the GI epithelium, urothelium, and Merkel cell Cornell, Michigan, TAMU, UCDavis
Cytokeratin 5 mesothelioma Purdue
Cytokeratin 5/6 basal cells or myoepithelial cells Michigan, UCDavis, UGA
Cytokeratin 7 CK7; + mammary gland carcinomas and canine cholangiocarcinomas Cornell, CSU, LADDL, Michigan, Purdue, TAMU, UCDavis
Cytokeratin 8 (CAM 5.2) carcinoma UCDavis
Cytokeratin HMW Cytokeratins 1, 5, 10 and 14 (carcinomas) Michigan, Purdue, UCDavis, UGA
Cytokeratin LMW UCDavis
Cytokeratin LMW 8/18 Apocrine sweat glands (double 8/18), single CK8-expression (hair follicle tumors) Purdue, UCDavis, UGA
Cytokeratin Plus, Pan AE1/AE3 + 8/18 UGA
Cytokeratin, Pan (MNF116) LADDL, Michigan
Cytokeratin, Pan AE1/AE3 CPath-UGA, Cornell, CSU, KSU, LADDL, Michigan, NC, ND, Nebraska, Purdue, TAMU, UCDavis, UGA, UF, WSU
Cytokeratin, Pan Lu-5 Multiple cytokeratins (clone Lu5) UCDavis, UGA
D2-40 podoplanin; germ cells and lymphatic endothelium UConn
Desmin Filament of skeletal and cardiac muscle CPath-UGA, Cornell, CSU, KSU, LADDL, Michigan, Nebraska, ND, Purdue, TAMU, UCDavis, UGA, UF, WSU
Desmoglein 1 and 2 skin junctions Michigan
Desmoplakin 1 and 2 skin junctions Michigan
DOG-1 canine GIST CSU
Doublecortin (DCX) Marker for neurogenesis UGA
E-Cadherin Cadherin, cell adhesion molecule (breast cancer) CPath-UGA, Cornell, CSU, Michigan, Purdue, TAMU, UCDavis, UGA
EGFR Epidermal Growth Factor Receptor; cancer marker UGA
Endorphin Neural tissue Michigan
Epithelial Membrane Antigen epithelial cells of all types, mesothelial cells, perineural cells, and a subset of plasma cells UConn
ER Estrogen Michigan
ETV1 (RNAscope) canine GIST oncogene Cornell
Factor VIII related antigen Blood vessels CPath-UGA, CSU, KSU, LADDL, Michigan, Nebraska, ND, Purdue, TAMU, UCDavis, UGA, UF, WSU
Factor XIII-A skin UGA
Factor XIII-B skin UGA
FoxP3 Treg cells Cornell, UGA
FSH Follicle stimulating hormone Michigan
Gastrin G cells of stomach/ islets Cornell, Michigan, Purdue, TAMU
GATA-3 breast cancer prognostic Purdue
GFAP (Glial Fibrillary Acidic Protein) Neural tissue CPath-UGA, Cornell, CSU, KSU, LADDL, Michigan, Nebraska, ND, Purdue, TAMU, UCDavis, UGA, UF, WSU
GH Growth hormone Michigan, UCDavis
Glucagon alpha cells of islets CPath-UGA, Cornell, Michigan, TAMU, UCDavis, UGA
Glut1 Glucose receptor Purdue
Granzyme B apoptosis, tissue rejection UCDavis, UGA
HBME-1 thyroid tumors Purdue
Hepatocyte Specific Antigen (HSA) Hepatocellular Carcinomas Purdue, TAMU, UGA
HepPar-1 hepatocellular carcinoma Cornell, CSU, Michigan, TAMU
Her2 Mammary carcinoma Michigan, UGA
Histamine Mast cells UGA
HMB45 melanoma Michigan
IBA-1 Histiocytes/ microglia/ macrophages Cornell, CSU, Iowa, LADDL, Nebraska, NC, ND, TAMU, UCDavis, UGA, UF
IgA (bovine) UGA
IgA (canine) Michigan, UCDavis
IGF2 (Insulin-like Growth Factor) proliferation and apoptosis UGA
IgG (canine) KSU, Michigan, UCDavis, UGA
IgG (equine) UGA
IgG (no species given) Nebraska
IgM (canine) KSU, Michigan, UCDavis
INSM1 insulinoma-associated protein 1- neuroendocrine tumors UGA
Insulin islet beta cells CPath-UGA, Cornell, CSU, KSU, LADDL, Michigan, Purdue, TAMU, UCDavis, UGA, UF
Kappa light chains Michigan, LADDL
Ki67 proliferation marker CPath-UGA, Cornell, CSU, KSU, LADDL, Michigan, Nebraska, Purdue, TAMU, UCDavis, UGA
Ki67 (red) Michigan
Lambda light chain antibodies Michigan, TAMU, LADDL
Laminin Carcinoma, PNST Michigan, UCDavis
LH Luteinizing hormone Michigan
Lipoteichoic acid Cornell
Luna's method (Histochemical) eosinophils UF
Lysozyme CPath-UGA, CSU, KSU, LADDL, Purdue, TAMU, UCDavis, UGA
MAC387 macrophages CPath-UGA, Cornell, TAMU, UGA
Macrophage/microglia marker Purdue
MAP2 Cornell
Melan A melanoma CPath-UGA, Cornell, CSU, KSU, LADDL, Michigan, NC, ND, Nebraska, Purdue, TAMU, UCDavis, UGA, WSU
Met-enkephalin GI-neuroendocrine Michigan
MHC II (HLA-DR) CSU, LADDL, Purdue, UGA
Microglia TAMU
MITF Microphthalmia Transcription Factor- melanoma Michigan
MUM1 Plasma cells Cornell, CSU, KSU, LADDL, Michigan, NC, ND, Purdue, TAMU, UCDavis, UGA, UF, WSU
Muscle specific actin Cornell, Michigan, Purdue, TAMU, UF, WSU
Myelin Basic Protein (MBP) SMI94; myelin CPath-UGA, LADDL, UCDavis, UGA
Myeloid/histiocytic antigen calprotectin Purdue, LADDL
Myeloperoxidase Cornell, TAMU, UCDavis
Myogenin (Mygo) UCDavis
Myoglobin skeletal muscle Cornell, LADDL, Michigan, TAMU, UCDavis, UGA
Myoglobin D1 skeletal muscle Nebraska, TAMU
Myosin smooth muscle Purdue
Napsin A lung adenocarcinoma Purdue
Natural Killer Call- have not had in past Purdue
Nerve growth factor receptor NGFR Purdue
NeuN (Neuronal Nuclear Antigen & Neuron) neuronal differentiation Cornell, UCDavis, UGA
Neurofilament CPath-UGA, Cornell, CSU, LADDL, Michigan, Purdue, TAMU, UCDavis, UGA
Neuron Specific Enolase (NSE) Non-specific stain CPath-UGA, Cornell, KSU, LADDL, Michigan, Purdue, TAMU, UCDavis, UGA, UF
NOS2 Nitric oxide synthase 2- oral SCC UGA
OLIG2 oligodendroglioma Cornell, CSU, Purdue, TAMU, UCDavis, UGA
Osteocalcin CSU
Osteonectin (hSPARC) Michigan, UCDavis, UGA
p16 papilloma virus related cancer Michigan
p53 cancer CPath-UGA, Michigan
p63 SCC-cancer prognosis marker Michigan, Purdue
Pan Muscle Actin UCDavis
Pancreatic polypeptide (IAPP) amylin; islet amyloid Michigan, Purdue
Pancreatic trypsin CSU
Panel- CD3 and CD20 Lymphoma panel TAMU
Panel- CD3, CD79 or CD20 Lymphoma Panel UGA
Panel- CD3, CD79 or CD20, CD18, MHCII, Mac387, IBA1 Histiocytic Sarcoma Panel UGA
Panel- CD3, CD79, CD20 and CD21 Lymphoma Panel UGA
Panel- CD3, PAX5, CD20, BA-1 Leukocyte panel Cornell
Panel- CD3, PAX5, CK19, LTA, TLR-4 CCHS (histocytic sarcoma) panel Cornell
Panel- Chromogranin A, Synaptophysin, NSE Neuroendocrine Panel UGA
Panel- Cytokeratin: AE1/AE3, Lu-5, Vimentin, S100 Undifferentiated Tumor Panel UGA
Panel- cytokeratins AE1/AE3, Lu-5, 5&6, LMW and HMW Carcinoma Panel UGA
Panel- EGFR, Her-2, PDGF, PDGF-r, VEGF, VEGF-r, SCF and KIT Tyrosine kinase/recepto panel (cancer) Michigan
Panel- GFAP, S100, Neurofilament, OLIG2 Neural Panel UGA
Panel- Her-2, ER, PR, CK5/6, EGFR, ki67, p63, E-cad and P-cad Mammary tumor prognosis Michigan
Panel- Insulin, Glucagon, Somatostatin Pancreatic Islet Panel UGA
Panel- Ki67, c-KIT, AgNOR Mast Cell Tumor Prognostic Panel UGA
Panel- Lysozyme, E-Cad, CD11d, CD45, CD45RA Secondary Histiocytic Sarcoma Panel UGA
Panel- Melan A and PNL-2 Melanoma panel TAMU
Panel- Melan A, PNL2, S100 Melanoma Panel UGA
Panel- Pan cytokeratin and vWF Epithelioid Hemangiosarcoma Panel TAMU
Panel- s Melan A, PNL-2, TRP-1, TRP-2 Melanoma cocktail Michigan
Panel- SMA and c-kit GIST panel TAMU
Panel- vimentin, desmin, myoglobin, SMA (smooth muscle actin), S100, Factor VIIIra and CD31 Undifferentiated Sarcoma UGA
Panel-Alkaline phosphatase and RUNX2 Osteosarcoma panel TAMU
PARR testing (FFPE block) hematologic cancers Michigan
PAX-5 (Avian) B-lymphocytes Cornell
PAX-5 (Mammalian) B-lymphocytes Cornell, CSU, LADDL, Michigan, NC, ND, Nebraska, Purdue, UCDavis, UGA
PAX-8 marker for thyroid, renal, Müllerian, and thymic tumors Purdue
PCNA Proliferating Cell Nuclear Antigen- cancer marker CPath-UGA, Cornell, Michigan, Purdue, TAMU, UGA
PDL-1 cancer prognostic UGA
Periaxin Devil facial tumors, schwannomas Cornell, Purdue, UCDavis
PGP 9.5 neural and neuroendocrine tissues Cornell, Michigan, Purdue, UGA
Pinkerton (histochemical) inclusion bodies -rickettsia UF
PNL2 Melanoma Cornell, CSU, KSU, LADDL, Michigan, NC, Purdue, TAMU, UCDavis, UGA, UF, WSU
PR Progesterone Michigan
Prostate specific antigen Purdue
Prostatic acid phosphatase prostatic epithelial cells Michigan, UCDavis
PROX-1 Lymphatic vessels Cornell, UGA
PTH Parathyroid Hormone Cornell, LADDL, TAMU, UCDavis, UGA
PTH (canine) Parathyroid hormone (does not work in cats) Michigan
PTH-rp Parathyroid Hormone-Related Peptide- tumors UGA
Rack-1 IGF-1R and integrin signaling Purdue
RUNX2 Osteoblast differentiation UGA, TAMU
S-100 neural tissues CPath-UGA, Cornell, CSU, KSU, LADDL, Michigan, Nebraska, Purdue, TAMU, UCDavis, UGA
S100 P Purdue
Sarcomeric actin Cornell, LADDL, Purdue, TAMU
Skeletal myosin UCDavis
SMI 31 Phosphorylated NF H & M UCDavis
SMI 312 General pan axonal marker UCDavis
SMI 33 Nonphosphorylated NF H & M UCDavis
SMI 36 Phosphorylated NF H UCDavis
SMI 91 Myelin CNPase UCDavis
Smooth Muscle Actin (SMA) smooth muscle CPath-UGA, Cornell, KSU, LADDL, Michigan, ND, Purdue, TAMU, UCDavis, UGA, UF
Somatostatin neuroendocrine (hypothalamus, islets, gastric) Cornell, KSU, LADDL, Michigan, Purdue, UCDavis, UGA
SOX10 melanocytic and schwannian tumors, PNST LADDL, Michigan, TAMU, UGA
SOX2 multipotential neural stem cells Cornell
SSTR2 somatostatinoma Cornell
Surfactant Michigan, UCDavis
Synaptophysin Neuroendocrine cells CPath-UGA, Cornell, CSU, KSU, LADDL, Michigan, Nebraska, Purdue, TAMU, UCDavis, UGA, UF, WSU
Tamm-Horsfall Protein urinary protein Michigan
Thy-1 (CD90) CD90- lymphocytes Michigan, Purdue
Thyroglobulin Thyroid follicular cells CPath-UGA, Cornell, CSU, KSU, LADDL, Michigan, Purdue, TAMU, UCDavis, UGA
TLR-4 Toll like receptor (LPS) Cornell
Triple Neurofilament Protein (TNP) UCDavis
TRP-1 Melanoma TAMU, LADDL
TRP-2 Melanoma TAMU, LADDL
Tryosine hydroxylase Pheochromocytoma Purdue, TAMU
Tryptase mast cells CSU, KSU, Michigan, Nebraska, Purdue, UCDavis
TTF-1 Thyroid Transcription Factor (thyroid and lung- nuclear stain) Cornell, CSU, KSU, Purdue, TAMU, UCDavis, UGA, UF
TTF-1 (canine) dog only Michigan
Uroplakin II Bladder tumors Purdue
Uroplakin III Bladder tumors Cornell, CSU, Michigan, Purdue, TAMU, UCDavis
Vasoactive intestinal protein GI inflammation Michigan
VEGF blood vessels CSU
Villin colorectal and gastrointestinal cancer Michigan
Vimentin Mesenchymal CPath-UGA, Cornell, CSU, KSU, LADDL, Michigan, ND, Nebraska, NC, Purdue, TAMU, UCDavis, UF, WSU
Vimentin SP20 Mesenchymal UGA
Vimentin V9 Mesenchymal UGA
von Willebrand factor (vWF) Cornell, NC, TAMU
Wilms Tumor 1 (WT1) Nephroblastoma CPath-UGA, Cornell, Michigan, UGA
YFP Yellow Fluorescent Protein- recombinant marker UGA
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